Key result
Breathing 100% oxygen significantly attenuated the cutaneous vasodilator response to acetylcholine compared to room air (P < 0.05), suggesting hyperoxia impairs endothelial-mediated vasodilation.
Why the study?
Does breathing 100% O2 reduce endothelial-mediated vasodilation in the human skin in healthy subjects?
Does breathing 100% O2 reduce endothelial-mediated vasodilation in the human skin in healthy subjects?
p-value: p=<0.05
Isocapnic hyperoxia attenuates endothelium-dependent vasodilation in the skin of healthy humans, suggesting hyperoxia impairs endothelial function without altering vascular reactivity to nitric oxide.
Hyperoxia may impair endothelial function in healthy skin; hypothesis-generating for clinical populations and should not change practice.
The influence of hyperoxia on the cutaneous vasodilator responses to iontophoretic applications of acetylcholine (ACh) and sodium nitroprusside (SNP) was examined in healthy subjects. The breathing of 100% O(2) decreased (P < 0.05) the vasodilator response to Ach, but not to SNP, suggesting that hyperoxia attenuates endothelial-mediated vasodilation of the human skin.
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Fumio Yamazaki (2007) studied Healthy (n=10). 100% O2 breathing (Hyperoxia) vs. Room air (21% O2) was evaluated on Cutaneous vasodilator response to acetylcholine (ACh) (p=<0.05). Breathing 100% oxygen significantly attenuated the cutaneous vasodilator response to acetylcholine compared to room air (P < 0.05), suggesting hyperoxia impairs endothelial-mediated vasodilation.
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