Key result
G3 rotavirus was detected in 22.9% of rotavirus-positive hospitalized children with acute gastroenteritis, with G3P[8] being the most common genotype (18.3%).
Observational (n=502)
No
The high prevalence and genetic diversity of G3 rotavirus strains in Pakistan, including a potential N-linked glycosylation site not present in the RotaTeq vaccine, highlights the need for robust surveillance to inform vaccine strategies.
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Supports rotavirus surveillance in Pakistan; leaves open whether emerging G3 variants affect current vaccine performance.
Rotavirus A species (RVA) is the leading cause of severe diarrhea among children in both developed and developing countries. Among different RVA G types, humans are most commonly infected with G1, G2, G3, G4 and G9. During 2003-2004, G3 rotavirus termed as "new variant G3" emerged in Japan that later disseminated to multiple countries across the world. Although G3 rotaviruses are now commonly detected globally, they have been rarely reported from Pakistan. We investigated the genetic diversity of G3 strains responsible RVA gastroenteritis in children hospitalized in Rawalpindi, Pakistan during 2014. G3P[8] (18.3%; n = 24) was detected as the most common genotype causing majority of infections in children less than 06 months. Phylogenetic analysis of Pakistani G3 strains showed high amino acid similarity to "new variant G3" and G3 strains reported from China, Russia, USA, Japan, Belgium and Hungary during 2007-2012. Pakistani G3 strains belonged to lineage 3 within sub-lineage 3d, containing an extra N-linked glycosylation site compared to the G3 strain of RotaTeqTM. To our knowledge, this is the first report on the molecular epidemiology of G3 rotavirus strains from Pakistan and calls for immediate response measures to introduce RV vaccine in the routine immunization program of the country on priority.
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Umair et al. (2018) conducted an observational in Acute dehydrating gastroenteritis (n=502). Rotavirus A species (RVA) infection was evaluated on Prevalence of G3 rotavirus among rotavirus-positive samples. G3 rotavirus was detected in 22.9% of rotavirus-positive hospitalized children with acute gastroenteritis, with G3P[8] being the most common genotype (18.3%).
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