Key result
A novel P[6]G8 rotavirus strain was identified in 42% of specimens from children with acute diarrhea in Malawi, with the P[6] genotype present in 57% of strains overall.
Cross-Sectional (n=100)
No
The identification of serotype G8 rotavirus as a predominant strain in Malawi highlights significant viral diversity with implications for vaccine development in Africa.
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Rotavirus diversity in Malawi may affect vaccine performance; leaves open need for updated strain surveillance and efficacy trials.
One hundred rotavirus strains detected in children with acute diarrhea in Blantyre, Malawi, between July 1997 and January 1998 were characterized for G (VP7) and P (VP4) types by using multiplex, heminested, reverse transcription–polymerase chain reaction. A novel P[6]G8 rotavirus strain was identified in 42% of the specimens. The remaining strains comprised P[8]G3 (20%), P[6]G3 (10%), P[4]G8 (9%), P[6]G9 (3%), P[8]G4 (2%), P[6]G4 (2%), and P[4]G3 (1%). Rotavirus strains with mixed G or P types were identified in 2% of the specimens. Nine percent of the strains were nontypeable with the primers used. The P[6] genotype was identified in 57% of strains overall. This first description of serotype G8 rotavirus as a predominant strain has important implications for vaccine development in Africa. The finding of novel P/G combinations (P[6]G8 and P[4]G8) highlights the extraordinary diversity of rotaviruses in some countries. J. Med. Virol. 57:308–312, 1999.
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Cunliffe et al. (1999) conducted a cross-sectional in Acute diarrhea (n=100). Rotavirus infection was evaluated on Rotavirus G and P types. A novel P[6]G8 rotavirus strain was identified in 42% of specimens from children with acute diarrhea in Malawi, with the P[6] genotype present in 57% of strains overall.
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