Synthetic study demonstrates the production of benzofused carbacephams via solid-phase cycloaddition, indicating a high-yield route to multicyclic beta-lactams.
An efficient approach for the solid-phase synthesis of multicyclic β-lactam derivatives is described. The key step is the cycloaddition reaction between an immobilized ketene and different cyclic imines to afford the corresponding benzofused carbacepham derivatives in high yield for the overall synthetic sequence.
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Méndez et al. (2010) studied this question.
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