Answers are grounded in this paper and cite their sources.
Experimental study reveals transition-metal-free cycloisomerization in 2-alkynylbenzamides promoted by water, indicating a green route to (Z)-3-alkylideneisoindolin-1-ones.
An alkali‐metal promoted cycloisomerization reaction of 2‐alkynylbenzamides is described for the synthesis of useful ( Z )‐3‐alkylideneisoindolin‐1‐one derivatives in modest to good yields and excellent chemo‐ and regioselectivity. Superstoichiometric amounts of water was found to be crucial for this reaction, and no transition‐metal salts are necessary. This synthetically green protocol proceeds efficiently with 100% atom economy and tolerates a diverse number of functional groups.
No takes yet. Share an insight, caveat, or question.
Tan et al. (2018) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: