Novel Phthalimidine Synthesis. Mannich Condensation of o-Phthalaldehyde with Primary Amines using 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries

All articles of this category The 1:1 condensation reactions of o -phthalaldehyde with a variety of primary amines in the presence of excess 2-mercaptoethanol and 1,2,3-1 H -benzotriazole as ”dual synthetic auxiliaries” in MeCN for 13 h at room temperature afford 2-substituted phthalimidines (2,3-dihydroisoindol-1-ones) in fair to good isolated yields. phthalimidine - Mannich condensation - dual synthetic auxiliaries