This manuscript proposes a novel hypothesis regarding adipocyte dedifferentiation and discusses methodological challenges in this emerging area of research.
Hypothesis on lipid-retaining adipocyte division awaits validation; leaves open its relevance to adipose remodeling in cardiometabolic disease.
Based on our studies we propose the following hypothesis: mature, lipid-containing adipocytes possess the ability to undergo symmetrical or asymmetrical cell division, without losing lipid. While our research to discern the mechanism(s) involved in what we have termed 'dedifferentiation' of adipocytes is ongoing, we have identified several roadblocks to our work in this area. However, due to the newness of this research, we believe that none of these problems discounts the potential importance of our initial observations, or the excitement of contributing knowledge in the area. In this manuscript we address some of these problems and suggest possible solutions in an attempt to make 'molehills' out of 'mountains.'
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Fernyhough et al. (2006) studied this question.
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