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January 1, 2004Obesity ResearchOpen Access

Upper and Lower Body Adipose Tissue Function: A Direct Comparison of Fat Mobilization in Humans

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Why the study?

Does fat mobilization and blood flow differ between gluteal and abdominal adipose tissues in humans?

Population

Humans in a small-scale physiological study

Comparison

Assessment of gluteal adipose tissue function vs Assessment of abdominal adipose tissue function

Design

Other

Authors

GTGarry D. TanNational Health ServiceGGGijs H. GoossensNovartis (Switzerland)SHSandy M. HumphreysChurchill Hospital

Discussion

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Overview

May explain lower CV risk with lower-body fat; hypothesis-generating for depot-specific mechanisms.

Structured PICO

Does fat mobilization and blood flow differ between gluteal and abdominal adipose tissues in humans?

P
Population
Humans in a small-scale physiological study
I
Intervention
Assessment of gluteal adipose tissue function
C
Comparator
Assessment of abdominal adipose tissue function
O
Outcome
Fat mobilization (adipose tissue blood flows, arterio-venous differences of metabolites, and gene expression)surrogate

Gluteal adipose tissue is metabolically 'silent' in terms of fatty acid release compared with abdominal adipose tissue, which may help explain the differential cardiovascular risk associated with upper versus lower body fat distribution.

Cite This Study

Tan et al. (2004) studied this question.

synapsesocial.com/papers/6a7387518412e8bdfca72c60https://doi.org/10.1038/oby.2004.15
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Flow through Human Adipose Tissue Determined with Radioactive Xenon1966 · 338 citations
  2. 2Regional postprandial fatty acid metabolism in different obesity phenotypes.1999 · 250 citations
  3. 3Interstitial glycerol concentration measured by microdialysis in two subcutaneous regions in humans1990 · 83 citations