Population
Normal weight women
Comparison
Subcutaneous adipose tissue sampling from four… vs Comparison between the four different…
Design
Cross-sectional
Key result
Gene expression profiling of four subcutaneous adipose depots in normal weight women revealed 2,890 differentially expressed transcripts, demonstrating regional heterogeneity in SAT biology.
Authors
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Regional SAT heterogeneity may guide depot-specific sampling in obesity research; leaves open clinical relevance for cardiometabolic risk.
Cross-Sectional
Subcutaneous adipose tissue exhibits significant regional heterogeneity in gene expression, challenging the assumption that it is a homogeneous depot.
Rehrer et al. (2012) conducted a cross-sectional in Healthy (normal weight). Subcutaneous adipose tissue sampling from four depots vs. Between-depot comparison (upper abdomen, lower abdomen, flank, and hip) was evaluated on Differential gene expression across four subcutaneous adipose depots. Gene expression profiling of four subcutaneous adipose depots in normal weight women revealed 2,890 differentially expressed transcripts, demonstrating regional heterogeneity in SAT biology.
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