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May 24, 2012ObesityOpen Access

Gene expression profiling of four subcutaneous adipose depots in normal weight women revealed 2,890 differentially expressed transcripts, demonstrating regional heterogeneity in SAT biology.

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Population

Normal weight women

Comparison

Subcutaneous adipose tissue sampling from four… vs Comparison between the four different…

Design

Cross-sectional

Key result

Gene expression profiling of four subcutaneous adipose depots in normal weight women revealed 2,890 differentially expressed transcripts, demonstrating regional heterogeneity in SAT biology.

Authors

CRCharles W. RehrerAKAnis Karimpour‐FardTHTeri L. Hernandez

Discussion

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Overview

Regional SAT heterogeneity may guide depot-specific sampling in obesity research; leaves open clinical relevance for cardiometabolic risk.

Study Design

Type

Cross-Sectional

Structured PICO

P
Population
Normal weight women
I
Intervention
Subcutaneous adipose tissue sampling from four depots (upper abdomen, lower abdomen, flank, and hip)
C
Comparator
Comparison between the four different subcutaneous adipose depots
O
Outcome
Differential gene expression (measured via Affymetrix GeneChip Human Exon 1.0 ST Arrays)surrogate

Subcutaneous adipose tissue exhibits significant regional heterogeneity in gene expression, challenging the assumption that it is a homogeneous depot.

Cite This Study

Rehrer et al. (2012) conducted a cross-sectional in Healthy (normal weight). Subcutaneous adipose tissue sampling from four depots vs. Between-depot comparison (upper abdomen, lower abdomen, flank, and hip) was evaluated on Differential gene expression across four subcutaneous adipose depots. Gene expression profiling of four subcutaneous adipose depots in normal weight women revealed 2,890 differentially expressed transcripts, demonstrating regional heterogeneity in SAT biology.

synapsesocial.com/papers/6a16d64287c007abbc052ecbhttps://doi.org/10.1038/oby.2012.117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Survey of Genes Differentially Expressed in Subcutaneous and Visceral Adipose Tissue in Men*2004 · 328 citations
  2. 2Abdominal versus femoral subcutaneous fat gene expression in non-obese insulin resistant individuals2026
  3. 3Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications2014 · 193 citations
  4. 4Gene Expression Patterns in Visceral and Subcutaneous Adipose Depots in Rats are Linked to Their Morphologic Features2009 · 72 citations
  5. 5Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response2010 · 117 citations