Key result
During an 8-year surveillance in São Paulo, Brazil, group A rotavirus was detected in 25.0% of acute gastroenteritis cases, with G1 being the predominant serotype (68.2%) followed by the emerging G9 serotype (17.2%).
Observational (n=3,101)
Yes
The emergence and high frequency of rotavirus G9 in São Paulo, Brazil, highlights the need for ongoing strain surveillance to inform the development and evaluation of future rotavirus vaccines.
Supports ongoing rotavirus strain surveillance in Brazil; leaves open whether G9 emergence requires vaccine updates.
A total of 3,101 fecal specimens were collected during an 8-year survey for rotavirus infection in São Paulo, Brazil. Group A rotavirus was detected in 774 (25.0%) specimens. Of these, 431 strains (55.7%) were analyzed for G and P types by reverse transcription-polymerase chain reaction; G1 was the predominant serotype (68.2%), followed by G9 (17.2%), G4 (6.3%), G2 (1.2%), G3 (0.7%), mixed infection (1.8%), and untypeable (4.6%). Both rotavirus G and P types could be established in 332 strains (77.0%). We identified the 4 most common strains worldwide: P[8]G1 (66.6%), P[4]G2 (1.0%), P[8]G3 (0.6%), and P[8]G4 (7.2%). Among the single G9 strains detected, VP4 genotyping showed that P[8]G9 was the most prevalent, followed by P[4]G9 and P[6]G9. The emergence and high frequency of rotavirus G9 in São Paulo, Brazil, and other parts of the world will affect the development and evaluation of future vaccines.
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Carmona et al. (2006) conducted an observational in Acute gastroenteritis (n=3,101). Rotavirus infection was evaluated on Prevalence of group A rotavirus and distribution of G and P types. During an 8-year surveillance in São Paulo, Brazil, group A rotavirus was detected in 25.0% of acute gastroenteritis cases, with G1 being the predominant serotype (68.2%) followed by the emerging G9 serotype (17.2%).
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