Key result
Familial hypercholesterolemia is more prevalent than initially thought, reaching 1 in 81 in certain regions of Quebec, with cardiovascular risk modulated by clinical and genetic variables.
Familial hypercholesterolemia is highly prevalent, especially in the French-Canadian population, and its cardiovascular risk is modulated by both genetic and clinical variables beyond just LDL-cholesterol.
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May support targeted FH screening in high-prevalence regions; leaves open refined risk models incorporating genetic-clinical modifiers.
Paquette et al. (2018) conducted a review in Familial hypercholesterolemia. Familial hypercholesterolemia was evaluated. Familial hypercholesterolemia is more prevalent than initially thought, reaching 1 in 81 in certain regions of Quebec, with cardiovascular risk modulated by clinical and genetic variables.
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