Key result
Platelet adhesion in the microcirculation, mediated by specific adhesion molecules and regulated by nitric oxide and superoxide, contributes significantly to tissue injury in animal models of disease.
Population
Animal models of human disease focusing on the microcirculation
Design
Review
Authors
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May guide preclinical targeting of platelet adhesion; leaves open translation to human microcirculatory disease.
Platelet-vessel wall interactions in the microcirculation play a significant role in the initiation and progression of tissue injury in various disease models.
Tailor et al. (2005) conducted a review in Tissue injury in animal models of human disease. Platelet-vessel wall interactions was evaluated. Platelet adhesion in the microcirculation, mediated by specific adhesion molecules and regulated by nitric oxide and superoxide, contributes significantly to tissue injury in animal models of disease.
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