Key result
A 7-week-old female infant developed hypoprothrombinemic bleeding and recurrent epistaxis while being fed a new soy formula (Isomil).
Case Report (n=1)
Highlights a case of hypoprothrombinemic bleeding in an infant fed a specific soy formula, suggesting potential vitamin K deficiency.
May signal vitamin K deficiency risk with soy formula in infants; single case leaves open need for confirmation or supplementation guidelines.
THE VITAMIN K requirement of young infants is minimal1and usually is fulfilled by the normal infant diet. Goldman and Desposito2presented case reports of five infants who developed hypoprothrombinemic bleeding while receiving formulas of low vitamin K content. These authors presented data indicating that soy formulas (Sobee, Mull-Soy) are high in vitamin K, higher in fact than whole cow's milk or commercially prepared skimmed cow's milk products with added vegetable oil (Enfamil, Similac). The following case is reported because the patient developed hypoprothrombinemic bleeding while being fed a new soy formula (Isomil). Report of a Case A 7-week-old female infant was hospitalized because of recurrent epistaxis. There was no family history of bleeding disorders. Birth weight was 3.7 kg (8 lb, 1 ounce). The infant had received 1.25 mg of menadione sodium bisulfite (Hykinone) intramuscularly shortly after delivery. Initial feedings consisted of a proprietary cow's milk formula.
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Malcolm H. Moss (1969) conducted a case report in Hypoprothrombinemic bleeding (n=1). Isomil (soy formula) was evaluated on Hypoprothrombinemic bleeding. A 7-week-old female infant developed hypoprothrombinemic bleeding and recurrent epistaxis while being fed a new soy formula (Isomil).
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