Key result
After denervation in adult mice, increases in mRNA levels of myogenin, MyoD1, and MRF4 accompany that of the acetylcholine receptor alpha-subunit mRNA.
Myogenic genes may play a role in mediating nerve influence on muscle differentiation and AChR alpha-subunit gene expression.
Suggests myogenic factors mediate denervation effects on AChR in mice; hypothesis-generating for nerve-muscle signaling.
The mRNA levels of the acetylcholine receptor alpha-subunit gene and of four members of the MyoD1 gene family, which code for candidate transcriptional activators of the former gene, were compared in the mouse during post-natal development and after denervation in the adult. During post-natal development, mRNA levels of myogenin, MyoD1, and Myf5 decrease in parallel with alpha-subunit mRNA whereas MRF4 mRNA level remains nearly constant. After denervation, increases in the levels of mRNAs coding for myogenin, MyoD1 and MRF4 accompany that of alpha-subunit mRNA, while Myf5 mRNA level varied little. A possible role of these myogenic genes in mediating nerve influence on the state of muscle differentiation and AChR alpha-subunit gene expression is discussed.
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Duclert et al. (1991) studied this question. Denervation was evaluated on mRNA levels of acetylcholine receptor alpha-subunit and MyoD1 gene family. After denervation in adult mice, increases in mRNA levels of myogenin, MyoD1, and MRF4 accompany that of the acetylcholine receptor alpha-subunit mRNA.
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