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April 3, 1993Veterinary Record

Investigation of vaccine reactions and breakdowns after feline calicivirus vaccination

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Key result

Feline calicivirus vaccination reactions were predominantly associated with lameness (80%), whereas vaccine breakdowns were mostly associated with acute oral/respiratory disease (24 of 31 cases).

Why the study?

What are the clinical and epidemiological features of feline calicivirus associated vaccine reactions and breakdowns?

Population

Cats with feline calicivirus associated vaccine reactions (n=123) and breakdowns (n=31)

Design

Case_series

Authors

SDSusan DawsonUniversity of ManchesterFMF. McArdleThe University of SydneyDBDavid BennettUniversity of Oxford

Discussion

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Implication

May guide differentiation of feline vaccine reactions from breakdowns; hypothesis-generating pending larger prospective studies.

Study Design

Type

Observational (n=154)

Structured PICO

What are the clinical and epidemiological features of feline calicivirus associated vaccine reactions and breakdowns?

P
Population
154 cases of feline calicivirus associated vaccine reactions (123 cases) and breakdowns (31 cases).
E
Exposure
Feline calicivirus vaccination
O
Outcome
Clinical and epidemiological features of vaccine reactions and breakdownssafety

Feline calicivirus vaccine reactions are frequently associated with lameness, while vaccine breakdowns are more often associated with acute oral/respiratory disease.

Cite This Study

Dawson et al. (1993) conducted an observational in Feline calicivirus associated vaccine reactions and breakdowns (n=154). Feline calicivirus vaccination was evaluated on Clinical signs and virus isolation. Feline calicivirus vaccination reactions were predominantly associated with lameness (80%), whereas vaccine breakdowns were mostly associated with acute oral/respiratory disease (24 of 31 cases).

synapsesocial.com/papers/6a99ca3270dc73aae64d2203https://doi.org/10.1136/vr.132.14.346
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Typing of feline calicivirus isolates from different clinical groups by virus neutralisation tests1993 · 64 citations
  2. 2Feline Calicivirosis in the catteries2024
  3. 3Modified-Live Feline Calicivirus Vaccination Reduces Viral RNA Loads, Duration of RNAemia, and the Severity of Clinical Signs after Heterologous Feline Calicivirus Challenge2021 · 16 citations
  4. 4A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease2009 · 41 citations
  5. 5Feline Caliciviral Disease: Experimental Immunoprophylaxis1976 · 16 citations