Key result
A validated UPLC method successfully and simultaneously estimated Metoprolol, Atorvastatin, and Ramipril in capsule dosage form with mean recoveries of 101.9%, 102.1%, and 101.4%, respectively.
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Supports simultaneous assay of fixed-dose cardiovascular capsules; leaves open routine adoption pending independent multi-lab verification.
A validated UPLC method was successfully developed for the simultaneous quantitative determination of metoprolol, atorvastatin, and ramipril in capsule dosage forms.
Raja Kumar Seshadri (2010) studied this question. Ultra performance liquid chromatographic (UPLC) method was evaluated on Method validation (linearity, accuracy, precision, specificity, robustness and ruggedness). A validated UPLC method successfully and simultaneously estimated Metoprolol, Atorvastatin, and Ramipril in capsule dosage form with mean recoveries of 101.9%, 102.1%, and 101.4%, respectively.
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