Key result
Cyclical transmission of T. gambiense isolates in rabbits and monkeys resulted in an ordered sequence of variant antigen production, suggesting antigenic variation is an adaptive process.
Population
Rabbits and monkeys infected with 3 isolates of T. gambiense by G. morsitans or G. tachinoides
Design
Preclinical
Authors
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Supports ordered antigenic variation in T. gambiense; hypothesis-generating for human vaccine or control strategies.
The ordered sequence of variant antigen production in T. gambiense infections supports the hypothesis that antigenic variation is an adaptive process rather than selection of mutants.
A. R. Gray (1975) studied Trypanosoma gambiense infection. Cyclical transmission of T. gambiense isolates was evaluated on Development of agglutinogenic antigens. Cyclical transmission of T. gambiense isolates in rabbits and monkeys resulted in an ordered sequence of variant antigen production, suggesting antigenic variation is an adaptive process.
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