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The integument is the largest organ in the human body and is a robust barrier to infection allowing for chronic implant of foreign materials that are non-carcinogenic. Skin layers act as a shield for the organs and provide protection against ultraviolet rays, burns, sores, infections, and tumors. 1,2 Basal cell carcinomas (BCC) are locally belligerent, rarely metastasizing epidermal tumors. 1,2 BCC is one of the most common tumors of the integument in the developed world.1 It appears mostly on the face and hair-bearing areas and is more frequently inhabiting areas more protected from sunlight.
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Burke et al. (2024) studied this question.
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