Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Xuri Li; Marc Tjwa; Lieve Moons; Pierre Fons; Agnès Noël; Annelii Ny; Jian Zhou; Johan Lennartsson; Hong Li; Aernout Luttun; Annica Pontén; Laetitia Devy; Ann Bouché; Hideyasu Oh; Ann Manderveld; Silvia Blacher; David Communi; Pierre Savi; Françoise Bono; Mieke Dewerchin; Jean‐Michel Foidart; Monica Autiero; Jean‐Marc Herbert; Désiré Collen; Carl‐Henrik Heldin; Ulf J. Eriksson; Peter Carmeliet

doi:10.1172/jci200419189

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The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/ PDGF superfamily, remain incompletely characterized.Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs.Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting.Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb.Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

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synapsesocial.com/papers/6a99cbbb1c6f8ccdb15585a7 https://doi.org/10.1172/jci200419189

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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

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