Key result
A pharmaceutical batch process for manufacturing Clopidogrel Bisulfate was successfully designed and simulated using AspenBatch and SuperPro Designer software packages.
This chemical engineering study demonstrates the successful computer-aided design, simulation, and economic evaluation of a batch manufacturing process for the anti-platelet drug clopidogrel bisulfate.
Simulation offers manufacturing optimization potential; extends process design tools but leaves clinical supply validation open.
A novel approach was taken in the fourth year design course for Chemical Engineers. A complex pharmaceutical process for the manufacturing of Clopidogrel Bisulfate (CPG), an anti-platelet drug, was successfully designed and simulated using AspenBatch™ and SuperPro Designer (SPD) software packages. Two models were applied in the design of the crystallizer and dryer, which provided the optimal cooling rate for crystallization and the surface area of the dryer. The solubility of CPG in acetone was determined experimentally by Attenuated Total Reflectance Fourier Spectroscopy (ATR-FTIR) instrument. Multifunctional equipment were designed to reduce the production and maintenance costs.
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Trifkovic et al. (2011) studied this question. Process simulation (AspenBatch and SuperPro Designer) was evaluated. A pharmaceutical batch process for manufacturing Clopidogrel Bisulfate was successfully designed and simulated using AspenBatch and SuperPro Designer software packages.
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