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October 1, 2004Emerging infectious diseasesOpen Access

Novel Recombinant Sapovirus

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Key result

Genetic analysis of two sapovirus strains revealed a novel, naturally occurring recombinant sapovirus with a recombination site likely located at the polymerase-capsid junction.

Authors

KKKazuhiko KatayamaHiroshima UniversityTMTatsuya MiyoshiSakai Municipal HospitalKUKiyoko Uchino

Discussion

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Implication

Novel sapovirus recombinants warrant genomic surveillance; leaves open questions on clinical impact and transmissibility.

PICO

P
Population
Two sapovirus strains isolated from infants with acute gastroenteritis in Thailand and Japan.
E
Exposure / Comparator
Genetic sequence analysis
O
Primary Outcome
Identification of recombination site

Limitations

  • Direct evidence for the recombination event is lacking
  • Unable to determine which strain was the parent and which was the progeny
  • Unsuccessful in expressing Mc10 VLPs to determine antigenicity

Cite This Study

Katayama et al. (2004) studied Acute gastroenteritis (n=2). Genetic sequence analysis was evaluated on Identification of recombination site. Genetic analysis of two sapovirus strains revealed a novel, naturally occurring recombinant sapovirus with a recombination site likely located at the polymerase-capsid junction.

synapsesocial.com/papers/6a99d2fedf56f4d2b41d7218https://doi.org/10.3201/eid1010.040395
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolution of Human Calicivirus RNA In Vivo:Accumulation of Mutations in the Protruding P2 Domain of the CapsidLeads to Structural Changes and Possibly a NewPhenotype2003 · 215 citations
  2. 2Genetic Diversity of Norovirus and Sapovirus in Hospitalized Infants with Sporadic Cases of Acute Gastroenteritis in Chiang Mai, Thailand2004 · 151 citations
  3. 3Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications2004 · 155 citations
  4. 4Diagnosis of Noncultivatable Gastroenteritis Viruses, the Human Caliciviruses2001 · 375 citations
  5. 5Identification of a Distinct Common Strain of “Norwalk‐like Viruses” Having a Global Distribution.1999 · 344 citations