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Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up. Ulceration may not appear for one to two weeks after initial injury. Wide local excision with subsequent split thickness skin grafting is recommended.
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Argenta et al. (1983) studied this question.
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