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May 30, 2017Frontiers in NeuroscienceOpen Access

Lower cognitive and language abilities in toddlers were significantly associated with a lower oxygenation variability index (r = 0.567, p = 0.001) and more extreme lateralization index values.

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Population

29 toddlers including typically developing and language delay groups.

Design

Cohort

Key result

Lower cognitive and language abilities in toddlers were significantly associated with a lower oxygenation variability index (r = 0.567, p = 0.001) and more extreme lateralization index values.

Authors

AAAfrouz AndersonESElizabeth G. SmithFCFatima Chowdhry

Discussion

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Overview

May support fNIRS for toddler neurodevelopmental research; leaves open clinical utility and causal links.

Study Design

Type

Cross-Sectional (n=29)

Multicenter

No

Structured PICO

P
Population
29 toddlers aged 18 to 43 months, including typically developing children and those with language delays, who underwent resting-state fNIRS.
E
Exposure
Functional near infrared spectroscopy (fNIRS) measurement of cerebral hemodynamics in the prefrontal cortex during a resting state (watching audiovisual children's programming).
O
Outcome
Oxygenation variability (OV) index and Lateralization Index based on oxy-hemoglobin saturation.surrogate

Main Result

Effect estimate: r = 0.567

p-value: p=0.001

fNIRS is a feasible tool for measuring prefrontal hemodynamics in toddlers, demonstrating that lower cognitive abilities are associated with lower oxygenation variability and more extreme lateralization indices.

Limitations

  • Small sample size
  • Lack of longitudinal follow-up to determine relation to change in developmental status
  • Activation measured during audiovisual presentation rather than specific cognitive tasks
  • Lack of integration of handedness data
  • Focus restricted to the prefrontal cortex due to sensor design
  • Small sample size requiring future studies to determine if findings are applicable to a larger population

Cite This Study

Anderson et al. (2017) conducted a cross-sectional in Language delay and typical development (n=29). Developmental ability (Composite Developmental Quotient) was evaluated on Correlation between Oxygenation Variability (OV) index and Composite Developmental Quotient (r = 0.567, p=0.001). Lower cognitive and language abilities in toddlers were significantly associated with a lower oxygenation variability index (r = 0.567, p = 0.001) and more extreme lateralization index values.

synapsesocial.com/papers/6a99d72620f0e2865a45a3f5https://doi.org/10.3389/fnins.2017.00300
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