Key result
Children with ADHD show ~67% lower left frontopolar cortex activation during go/no-go tasks versus controls.
Why the study?
Functional near-infrared spectroscopy (fNIRS) may detect differences in prefrontal cortex activation between children with ADHD and typically developing children during inhibitory tasks.
Does functional near-infrared spectroscopy (fNIRS) detect differences in prefrontal cortex activation between children with ADHD and typically developing children during a go/no-go task?
Case-Control (n=29)
No
Does functional near-infrared spectroscopy (fNIRS) detect differences in prefrontal cortex activation between children with ADHD and typically developing children during a go/no-go task?
fNIRS demonstrates reduced left prefrontal cortex activation in children with ADHD during inhibitory tasks, suggesting its potential utility as a diagnostic tool.
Answers are grounded in this paper and cite their sources.
fNIRS may differentiate prefrontal hemodynamics in small ADHD cohorts; leaves open its role as a diagnostic adjunct pending larger trials.
Objective: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children and affects 3% to 5% of school-aged children. This study is to demonstrate whether functional near-infrared spectroscopy (fNIRS) can detect the changes in the concentration of oxygenated hemoglobin(oxy-HB) in children with ADHD and typically developing children(TD children). Method: In this study, 14 children with ADHD and 15 TD children were studied. Metabolic signals of functional blood oxygen were recorded by using fNIRS during go/no-go task. A statistic method is used to compare the fNIRS between the ADHD children and controls. Results: A significant oxy-HB increase in the left frontopolar cortex(FPC) in control subjects but not in children with ADHD during inhibitory tasks. Moreover, ADHD children showed reduced activation in left FPC relative to TD children . Conclusion: Functional brain imaging using fNIRS showed reduced activation in the left prefrontal cortex(PFC) of children with ADHD during the inhibition task. The fNIRS could be a promising tool for differentiating children with ADHD and TD children.
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Miao et al. (2017) conducted a case-control in Attention-Deficit/Hyperactivity Disorder (ADHD) (n=29). Attention-Deficit/Hyperactivity Disorder (ADHD) vs. Typically developing children was evaluated on Change in oxygenated hemoglobin (oxy-HB) concentration in the left frontopolar cortex (CH48) during go/no-go task (mM·mm) (p=0.008). Children with ADHD exhibited significantly reduced activation in the left frontopolar cortex during a go/no-go task compared to typically developing children.
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