Key result
Boys with ADHD show hemoglobin imbalance during attention tasks instead of normal left prefrontal lateralization.
Why the study?
Prefrontal hemodynamic changes induced by cognitive tasks in children with attention-deficit disorder compared to normal controls had not been clearly evaluated using near-infrared spectroscopy.
Does near-infrared spectroscopy detect differences in cerebral hemodynamic changes during an executive function task between children with ADHD and healthy controls?
Population
11 boys with ADHD and 9 healthy age- and sex-matched controls
Comparison
Boys with ADHD vs healthy controls during a trail-making executive function task
Design
Case-control study
Authors
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NIRS may detect ADHD-related prefrontal hemodynamic imbalances; hypothesis-generating and should not yet change practice.
Case-Control (n=20)
Does near-infrared spectroscopy detect differences in cerebral hemodynamic changes during an executive function task between children with ADHD and healthy controls?
NIRS can detect distinct patterns of prefrontal hemodynamic responses and oxygen consumption during cognitive tasks in children with ADHD compared to healthy controls.
Hubert Fahnenstich (2005) conducted a case-control in Attention-deficit hyperactivity disorder (ADHD) (n=20). Attention-deficit hyperactivity disorder (ADHD) vs. Healthy age- and sex-matched controls was evaluated on Changes in oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin, tissue oxygenation index (TOI), and cerebral blood volume (CBV). Boys with ADHD showed an imbalance between oxygenated and deoxygenated hemoglobin during attention tasks, whereas healthy controls showed lateralized oxygen consumption in the left prefrontal cortex.
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