Key result
ACE gene I/D polymorphism was not significantly associated with PCOS overall, but the D allele increased risk in Caucasians compared to the I allele (OR 1.48; 95% CI 1.00-2.19).
Why the study?
Is the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism associated with an increased risk of polycystic ovary syndrome?
Meta-Analysis (n=2,224)
Is the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism associated with an increased risk of polycystic ovary syndrome?
Odds Ratio: 1.48 (95% CI 1–2.19)
The ACE I/D polymorphism is associated with an increased risk of PCOS in Caucasian populations, but not in Asian populations.
INTRODUCTION: Epidemiological studies investigating the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis. MATERIALS AND METHODS: PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models. RESULTS: Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00-2.19 for D vs. I; OR = 1.61, 95% CI, 1.14-2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04-1.97 for DD and DI vs. II), but not in Asians. CONCLUSIONS: Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings.
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Jia et al. (2012) conducted a meta-analysis in Polycystic ovary syndrome (PCOS) (n=2,224). Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism vs. I allele / II genotype was evaluated on Polycystic ovary syndrome (PCOS) (OR 1.48, 95% CI 1.00-2.19). ACE gene I/D polymorphism was not significantly associated with PCOS overall, but the D allele increased risk in Caucasians compared to the I allele (OR 1.48; 95% CI 1.00-2.19).
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