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June 1, 2002The Journal of Clinical Endocrinology & Metabolism

Variation within the Type 2 Diabetes Susceptibility Gene Calpain-10 and Polycystic Ovary Syndrome

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Why the study?

Does CAPN10 gene variation influence susceptibility to polycystic ovary syndrome (PCOS)?

Population

146 parent-offspring trios, 185 additional PCOS cases, and 525 control subjects, all of European ancestry

Comparison

CAPN10 gene variation vs Control subjects and non-transmitted alleles

Design

Case-control

Authors

LHLema HaddadLoma Linda UniversityJEJulie EvansNorth Bristol NHS TrustNGNeda GharaniCoriell Institute For Medical Research

Discussion

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Implication

No association in Europeans does not support CAPN10 testing for PCOS; leaves open ancestry-specific or subtype effects.

Structured PICO

Does CAPN10 gene variation influence susceptibility to polycystic ovary syndrome (PCOS)?

P
Population
146 parent-offspring trios, 185 additional PCOS cases, and 525 control subjects, all of European ancestry
I
Intervention
CAPN10 gene variation (SNP-44, SNP-43, SNP-19, SNP-63)
C
Comparator
Control subjects and non-transmitted alleles
O
Outcome
Association with polycystic ovary syndrome (PCOS) susceptibility

CAPN10 gene variation does not appear to influence susceptibility to polycystic ovary syndrome in populations of European ancestry.

Cite This Study

Haddad et al. (2002) studied this question.

synapsesocial.com/papers/6a99da8df9da1bc1819e33bbhttps://doi.org/10.1210/jcem.87.6.8608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)1989 · 2,517 citations
  2. 2Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*1997 · 2,468 citations
  3. 3Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.2000 · 189 citations
  4. 4Selective Insulin Resistance in the Polycystic Ovary Syndrome11999 · 172 citations
  5. 5Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene2001 · 38 citations