Key result
Polycystic ovary syndrome was an independent determinant of a more atherogenic non-A LDL pattern compared with matched controls (12.9% vs 2.9%; OR 5.48; 95% CI 1.082-27.77; P<0.05).
Why the study?
Does PCOS status independently increase atherogenic lipid profiles in women matched for BMI and insulin resistance?
Case-Control (n=140)
Does PCOS status independently increase atherogenic lipid profiles in women matched for BMI and insulin resistance?
Odds Ratio: 5.48 (95% CI 1.082–27.77)
Absolute Event Rate: 12.9% vs 2.9%
p-value: p=<0.05
Women with PCOS have a more atherogenic lipid profile, including higher VLDL and non-A LDL patterns, independent of BMI and insulin resistance.
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May elevate CVD risk perception in PCOS beyond BMI/IR; hypothesis-generating and requires prospective validation.
Phelan et al. (2010) conducted a case-control in Polycystic Ovary Syndrome (PCOS) (n=140). Polycystic Ovary Syndrome (PCOS) vs. Normal women without PCOS matched for age, BMI, and insulin resistance was evaluated on Non-A LDL pattern (OR 5.48, 95% CI 1.082-27.77, p=<0.05). Polycystic ovary syndrome was an independent determinant of a more atherogenic non-A LDL pattern compared with matched controls (12.9% vs 2.9%; OR 5.48; 95% CI 1.082-27.77; P<0.05).
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