Key result
Children and adolescents in the highest quartile of the systemic immune-inflammation index had an 83% higher risk of developing central obesity over a 2-year period compared to those in the lowest quartile.
Why the study?
Does a higher systemic immune-inflammation index predict the development of central obesity in pediatric populations?
Observational (n=4,730)
No
Does a higher systemic immune-inflammation index predict the development of central obesity in pediatric populations?
Relative Risk: 1.83 (95% CI 1.18–2.83)
p-value: p=<0.01
An elevated systemic immune-inflammation index is significantly associated with an increased risk of developing central obesity in children and adolescents, suggesting its potential as an early biomarker for obesity-related metabolic risk.
SII may mark inflammation tied to pediatric central obesity; leaves open predictive value and causality for prospective trials.
Background: Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored. The objective of this study was to examine the relationship between SII and central obesity, with a particular focus on the potential of SII as a predictor of central obesity and a means of preventing obesity at an early stage of life. Methods: Waist-to-height ratio (WHtR), subcutaneous fat, and visceral fat were employed as obesity proxies. Central obesity was defined according to WHtR with a cutoff value of 0.46. The implications of SII on central obesity were examined in a sample of 4,730 individuals in 2021 and validated through a prospective study involving 1,425 subjects in 2023. Cross-sectional associations between SII and central obesity were examined using binomial logistic regression models and generalized linear models. The restricted cubic spline regression was used to explore the non-linear relationship between SII and obesity indicators. In a prospective study, we employed a modified Poisson regression model to investigate the potential causal relationship between SII and central obesity. Results: Cross-sectionally, adolescents in the highest quartile of SII levels exhibited the greatest risk for central obesity(OR=3.07, 95% CI:2.45~3.87) when compared to those in the lowest quartile. Subgroup analyses showed that higher SII was associated with central obesity. Longitudinally, individuals in the highest SII quartile were found to have the highest risk of developing central obesity (RR=1.83, 95% CI:1.18~2.83) over time.
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Zhang et al. (2025) conducted an observational in Central obesity (n=4,730). Systemic immune-inflammation index (SII) vs. Lowest quartile of SII was evaluated on Development of central obesity (waist-to-height ratio > 0.46) (RR 1.83, 95% CI 1.18-2.83, p=<0.01). Children and adolescents in the highest quartile of the systemic immune-inflammation index had an 83% higher risk of developing central obesity over a 2-year period compared to those in the lowest quartile.
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