Key result
Higher Systemic Immune-Inflammation Index (SII) was significantly associated with the presence of metabolic syndrome in obese children and adolescents (OR 1.005), demonstrating better discriminative ability than SIRI.
Why the study?
With rising pediatric obesity and metabolic syndrome worldwide, early identification of children with obesity who are prone to developing metabolic syndrome is important.
Do the Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) predict the presence of metabolic syndrome in obese children and adolescents?
Population
99 children and adolescents with obesity
Comparison
MetS+ (n = 42) vs MetS- (n = 57)
Design
Prospective single-center cross-sectional study
Authors
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SII/SIRI may aid MetS risk stratification in obese youth; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=99)
No
Do the Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) predict the presence of metabolic syndrome in obese children and adolescents?
Odds Ratio: 1.005 (95% CI 1.002–1.008)
p-value: p=0.003
The Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) derived from routine blood counts can serve as accessible biomarkers for the early identification of metabolic syndrome in obese children and adolescents.
Gayret et al. (2024) conducted a cross-sectional in Obesity and Metabolic Syndrome (n=99). Systemic Immune-Inflammation Index (SII) vs. Lower SII values was evaluated on Presence of Metabolic Syndrome (MetS) (OR 1.005, 95% CI 1.002-1.008, p=0.003). Higher Systemic Immune-Inflammation Index (SII) was significantly associated with the presence of metabolic syndrome in obese children and adolescents (OR 1.005), demonstrating better discriminative ability than SIRI.
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