Key result
Elevated Systemic Immune-Inflammation Index is linked to ~34% greater odds of metabolic syndrome.
Why the study?
The systemic immune-inflammation index has emerged as a potential inflammatory biomarker, but its role in metabolic syndrome remains unclear.
Is the Systemic Immune-Inflammation Index (SII) associated with metabolic syndrome?
Meta-Analysis
Is the Systemic Immune-Inflammation Index (SII) associated with metabolic syndrome?
Odds Ratio: 1.34 (95% CI 1.08–1.67)
p-value: p=<.01
The Systemic Immune-Inflammation Index is significantly associated with metabolic syndrome, though its diagnostic accuracy is currently limited and requires further prospective research.
No takes yet. Share an insight, caveat, or question.
SII elevation may support MetS risk stratification in practice; leaves open whether it adds value beyond conventional markers in prospective studies.
Mahapatro et al. (2026) conducted a meta-analysis in Metabolic syndrome. Systemic Immune-Inflammation Index (SII) vs. Lower SII was evaluated on Metabolic syndrome (OR 1.34, 95% CI 1.08-1.67, p=<.01). An elevated Systemic Immune-Inflammation Index was significantly associated with increased odds of metabolic syndrome (OR 1.34; 95% CI 1.08-1.67; P<0.01).
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