What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

To examine the relationship between the systemic immune inflammation index and hypertension outcomes.

November 10, 2025Frontiers in Cardiovascular MedicineOpen Access

Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis

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Authors

SSShude Sun JFJiamei Fu JYJianfei Yang

Discussion

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Implication

Meta-analysis reveals elevated SII correlates with increased incidence and worsened clinical outcomes in hypertension patients, suggesting its role as a prognostic marker.

Key Points

To examine the relationship between the systemic immune inflammation index and hypertension outcomes.
Conducted systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library.
Analyzed standardized mean difference and odds ratios to determine association strength.
Performed subgroup analyses based on study design, sample size, region, and mean age.
High SII is associated with increased incidence of hypertension with SMD = 1.22 and OR = 1.14.
Patients with high SII show higher rates of mortality and cardiovascular events than those with low SII.
Carotid intima-media thickness and asymptomatic organ damage are greater in high SII group.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/69253a1ec0ce034ddc356f81 https://doi.org/10.3389/fcvm.2025.1593481

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Implication

Meta-analysis reveals elevated SII correlates with increased incidence and worsened clinical outcomes in hypertension patients, suggesting its role as a prognostic marker.

Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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