A study was undertaken to ascertain the morphological differences that exist between the primary tumor and the metastatic deposits of 55 selected cases of Wilms' tumors. The observations in this study point towards a greater degree of non-epithelial differentiation and a decrease in the tubular and glomerular differentiation in the metastases as compared to the primary tumors. The study also suggests that irradiation accelerates and possibly induces non-epithelial differentiation.
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Bannayan et al. (1971) studied this question.
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