Key result
Intraarterial administration of tirofiban resulted in complete resolution of acute carotid stent thrombosis within 15 minutes and complete clinical recovery at 30 days in a single patient.
Case Report (n=1)
Intraarterial tirofiban administration successfully resolved acute carotid stent thrombosis and associated neurological deficits in a patient on standard antiplatelet therapy.
May offer rescue option in acute carotid stent thrombosis; single case leaves open need for prospective validation.
Fifty minutes following implantation of a right internal carotid artery stent, left lower extremity paresis developed in a patient despite use of heparin, clopidogrel and aspirin. Immediate angiograms revealed partially thrombosed carotid stent, then tirofiban (a glycoprotein IIb-IIIa receptor inhibitor) was administered intraarterially into the stent. After 15 minutes, complete resolution of the thrombus was detected on repeat angiography. The patient had recovered completely at 30-day follow-up.
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Oran et al. (2005) conducted a case report in Acute carotid stent thrombosis (n=1). Intraarterial tirofiban was evaluated on Resolution of thrombus and clinical recovery. Intraarterial administration of tirofiban resulted in complete resolution of acute carotid stent thrombosis within 15 minutes and complete clinical recovery at 30 days in a single patient.
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