Key result
Children with true isolated growth hormone deficiency entered puberty at an average bone age of 12.0 years for boys and 10.9 years for girls, closely matching normal children.
Why the study?
At what bone age do patients with true isolated growth hormone deficiency enter puberty?
Observational (n=26)
At what bone age do patients with true isolated growth hormone deficiency enter puberty?
Patients with true isolated growth hormone deficiency enter puberty at a bone age very close to that of normal children.
Supports normal bone age thresholds for puberty assessment in isolated GH deficiency; leaves open effects on management or outcomes.
Nineteen boys with true isolated growth hormone deficiency developed the first stages of puberty at an average bone age of 12.0"years" (Tanner Whitehouse Method 2, RUS score). The average chronological age was 15.0 years. Seven similar girls entered puberty at 10.9"years" in bone age and 13.7 years in chronological age. The means and ranges of bone age at beginning of puberty of these patients are very close to those of normal children.
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Tanner et al. (1975) conducted an observational in True isolated growth hormone deficiency (n=26). True isolated growth hormone deficiency vs. Normal children was evaluated on Bone age at the first stages of puberty. Children with true isolated growth hormone deficiency entered puberty at an average bone age of 12.0 years for boys and 10.9 years for girls, closely matching normal children.
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