What question did this study set out to answer?

To assess the long-term incidence and risk of clinical hyperparathyroidism and associated thyroid cancer following childhood radiation exposure to the tonsils.

August 1, 1990JAMA

A Prospective Study of Hyperparathyroidism in Individuals Exposed to Radiation in Childhood

View Full Paper

Ask AI

Bookmark

Authors

JCJoel E. CohenUniversity of Chicago

Discussion

Member takes

Implication

Prospective cohort study finds elevated hyperparathyroidism incidence in adults exposed to childhood radiation, highlighting the need for routine parathyroid screening.

Key Points

To assess the long-term incidence and risk of clinical hyperparathyroidism and associated thyroid cancer following childhood radiation exposure to the tonsils.
Prospective cohort study following 4,297 patients who underwent tonsillar irradiation before age 16 years.
Tracked and analyzed clinical outcomes for 2,923 located patients who provided follow-up information.
Clinical hyperparathyroidism developed in 32 patients, with an incidence rate of 18.7 per 100,000 person-years before age 40 (2.9-fold increase; 95% CI, 1.6 to 4.3) and 171 per 100,000 person-years between ages 40 and 60 (2.5-fold increase; 95% CI, 1.1 to 3.9) relative to the general population.
Thyroid cancer occurred in 31% of patients with hyperparathyroidism compared to 11.2% in irradiated patients who did not develop parathyroid tumors.

Cite This Study

Joel E. Cohen (1990) studied this question.

synapsesocial.com/papers/6a99dd37ebe8718ca5f50a7b https://doi.org/10.1001/jama.1990.03450050039024

View Full Paper

Ask AI

Bookmark

Implication

Prospective cohort study finds elevated hyperparathyroidism incidence in adults exposed to childhood radiation, highlighting the need for routine parathyroid screening.

A Prospective Study of Hyperparathyroidism in Individuals Exposed to Radiation in Childhood

Discussion

Member takes

Implication

Key Points

Cite This Study

A Prospective Study of Hyperparathyroidism in Individuals Exposed to Radiation in Childhood

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider