Waldenström's Macroglobulinemia and Mononeuritis Multiplex

Brief Reports1 March 1978Waldenström's Macroglobulinemia and Mononeuritis MultiplexE. WAYNE MASSEY, A. BERNARD PLEET, WILLIAM L BRANNONE. WAYNE MASSEYSearch for more papers by this author, A. BERNARD PLEETSearch for more papers by this author, WILLIAM L BRANNONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-360 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary macroglobulinemia was first described by Waldenström in 1944 and appeared in the American literature in 1956 (1). This disease usually affects elderly persons and is characterized by weakness, weight loss, anemia, bleeding, lymphadenopathy, and hepatosplenomegaly. A marked increase in plasma IgM protein and bone marrow occurs, and lymph nodes and other tissues are infiltrated with lymphocytoid cells. One fourth of the patients with primary macroglobulinemia have neurologic complications, including focal or diffuse brain syndromes, polyneuritis, and subarachnoid hemorrhage (2). To our knowledge, only a single case report of mononeuritis multiplex in association with macroglobulinemia has been published (3). We...References1. VOIGTFRICK AP: Macroglobulinemia of Waldenström: a review of the literature and presentation of a case. Ann Intern Med 44:419-425, 1956 LinkGoogle Scholar2. LOGOTHETISSILVERSTEINCOE JPJ: Neurologic aspects of Waldenström's macroglobulinemia. Arch Neurol 3:564-573, 1960 CrossrefMedlineGoogle Scholar3. FRASERPARKERAMERCAMPBELL DASI: Mononeuritis multiplex in a patient with macroglobulinemia. J Neurol Neurosurg Psychiatry 39:711-715, 1976 CrossrefMedlineGoogle Scholar4. MICHONLARCANSTREIFF PAG: Neuropathies dysglobulinemiques. Rev Neurol (Paris) 100:27-40, 1959 MedlineGoogle Scholar5. GLENCHURZINNEMANBRIGGS HHD: Macroglobulinemia: report of two cases. Ann Intern Med 48:1055-1069, 1958 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USN National Naval Medical Center Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCase of mononeuritis multiplex onset with rituximab therapy for Waldenström's macroglobulinemiaMononeuritis multiplex in Waldenström's macroglobulinemiaWaldenstrom’s Macroglobulinemia and Nonmalignant IgM Monoclonal GammopathiesPolyneuropathy in paraproteinaemiaReactivity of sera and isolated monoclonal IgM from patients with waldenstr�m's macroglobulinaemia with peripheral nerve myelinMultiple exercise-related mononeuropathy with abdominal colicParaproteinaemia in neurological disease: incidence, associations, and classification of monoclonal immunoglobulins.Sjögren's Syndrome and Mononeuritis MultiplexE. WAYNE MASSEY, M.D.Neurologische Symptome bei der Makroglobulinämie WaldenstromMononeuropathy in diabetes mellitus 1 March 1978Volume 88, Issue 3Page: 360-361KeywordsBrainCellsElderlyHemorrhageHepatosplenomegalyLymph nodesMononeuritisPlasma proteinsSubarachnoid hemorrhageWeight loss Issue Published: 1 March 1978 PDF DownloadLoading ...