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March 1, 1989The Journal of Experimental MedicineOpen Access

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

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Authors

CPCarlo Federico PernoCentre International De Reference Chantal BiyaRYRobert YarchoanNational Institutes of HealthDCDavid A. CooneyNational Institutes of Health

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Perno et al. (1989) studied this question.

synapsesocial.com/papers/6a99e05695d477d8a1f50954https://doi.org/10.1084/jem.169.3.933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins1985 · 1,232 citations
  2. 2Expression of the M-CSF (CSF-1) gene by human monocytes1987 · 229 citations
  3. 3Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.1987 · 139 citations
  4. 4Biologic properties in vitro of a recombinant human granulocyte- macrophage colony-stimulating factor1986 · 455 citations
  5. 5Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.1988 · 232 citations