Why the study?
Are plasma renin activity and NT-proBNP levels associated with different types of atrial fibrillation in patients with normal left ventricular systolic function?
Cross-Sectional (n=182)
Are plasma renin activity and NT-proBNP levels associated with different types of atrial fibrillation in patients with normal left ventricular systolic function?
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NT-proBNP levels, but not plasma renin activity, are elevated in atrial fibrillation and correlate with the chronicity of the arrhythmia in patients with normal LV systolic function.
OBJECTIVE: Renin-angiotensin system may be activated during atrial fibrillation (AF). Our aim was to evaluate plasma renin activity (PRA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with different AF types who had normal left ventricular (LV) systolic function. METHODS: This cross-sectional study included 97 patients with recent ( or=1.9 ng/ml/hour (OR=1.1, 95% CI 1.01-1.23, p=0.03). With NT-proBNP level >or=52 pg/ml, independent predictors were age (OR=1.1, 95% CI 1.01-1.19, p=0.02), presence of persistent and/or permanent AF (OR=6.8, 95% CI 1.03-45.7, p=0.04) and left atrial dimension (OR=1.2, 95% CI 1.03-1.36, p=0.02). CONCLUSION: Plasma NT-proBNP levels can be associated with AF and its subtypes in patients with normal LV systolic function, whereas there was no association between PRA levels and AF.
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Doğan et al. (2010) conducted a cross-sectional in Atrial fibrillation (n=182). Persistent and/or permanent atrial fibrillation vs. Healthy controls was evaluated on NT-proBNP level ≥52 pg/ml (OR 6.8, 95% CI 1.03-45.7, p=0.04).
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