Key result
The pathophysiological mechanisms of liver steatosis in NAFLD are multifactorial, involving insulin resistance, fatty acid retention, oxidative stress, and altered transcriptional factor expression.
Population
Patients with nonalcoholic fatty liver disease (NAFLD)
Design
Review
Authors
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Multifactorial NAFLD mechanisms warrant holistic assessment; leaves open dominant pathway targeting for trials.
This review summarizes the multifactorial molecular mechanisms underlying NAFLD, emphasizing the role of insulin resistance and lipid metabolism alterations.
Pettinelli et al. (2012) conducted a review in Nonalcoholic fatty liver disease (NAFLD). The pathophysiological mechanisms of liver steatosis in NAFLD are multifactorial, involving insulin resistance, fatty acid retention, oxidative stress, and altered transcriptional factor expression.
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