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An Na + concentration gradient (outside > inside) drives the uphill transport of l‐aspartate and l‐glutamate in rat‐liver plasma membrane vesicles. Competition and exchange‐diffusion experiments indicate the presence of a transport system specific for l‐aspartate and l‐glutamate with a high substrate affinity: an apparent Km of 5.4 μM and 7.4 μM was found for l‐aspartate and l‐glutamate, respectively. The uphill transport is Na +‐specific, but also requires the presence of K + for optimal functioning. The possible physiological relevance of such a transport system is discussed.
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Sips et al. (1982) studied this question.
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