Key result
Yohimbine produced psychic and autonomic changes resembling anxiety in man, which were reduced by reserpine and amobarbital but paradoxically potentiated by chlorpromazine.
Why the study?
How do chlorpromazine, reserpine, amobarbital, and atropine modify the psychic and autonomic effects of yohimbine in man?
How do chlorpromazine, reserpine, amobarbital, and atropine modify the psychic and autonomic effects of yohimbine in man?
Chlorpromazine paradoxically potentiates the anxiety-like psychic and autonomic effects of yohimbine in humans.
Chlorpromazine may paradoxically worsen yohimbine-induced anxiety symptoms; leaves open relevance to modern anxiolytic or antipsychotic interactions.
Yohimbine was found to produce psychic and autonomic changes resembling anxiety in man. Chlorpromazine, reserpine, amobarbital and atropine modified the response to yohimbine. Both reserpine and amobarbital reduced the drug's psychic and autonomic effect, while atropine decreased the pressor response to yohimbine. Chlorpromazine acted paradoxically, potentiating both psychic and autonomic responses.
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Charles G. Ingram (1962) studied this question. Yohimbine was evaluated on Psychic and autonomic changes. Yohimbine produced psychic and autonomic changes resembling anxiety in man, which were reduced by reserpine and amobarbital but paradoxically potentiated by chlorpromazine.
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