What does this research mean for the field?

Wolff-Parkinson-White syndrome, fetal or late diagnosis, and the need for multi-antiarrhythmic therapy are independent clinical predictors of supraventricular tachycardia recurrence in infants. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify clinical characteristics and prognostic factors associated with the recurrence of supraventricular tachycardia during infancy.

September 3, 2026Journal of the American College of CardiologyOpen Access

Clinical Predictors of Recurrent Supraventricular Tachycardia in Infancy

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Supraventricular tachycardia (SVT) (n=460). Intervention: Wolff-Parkinson-White (WPW) syndrome vs. Absence of WPW syndrome. Primary outcome: First SVT recurrence after hospital discharge (HR 2.46, 95% CI 1.75-3.45).

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Key result

WPW syndrome linked to ~146% higher SVT recurrence risk in infants.

HR 2.46
95% CI 1.75-3.45
n=460

Why the study?

Data regarding recurrence risk among infants with supraventricular tachycardia (SVT) are limited.

Population

460 infants with structurally normal hearts diagnosed at age ≤1 year with re-entrant SVT

Comparison

Clinical factors and therapies associated with first SVT recurrence

Design

Retrospective single-center study with prospective phone follow-up

Follow-up

Median 5.2 years

Authors

JMJudson A. MooreUniversity of Utah SSSara B. StephensBaylor College of Medicine NKNaomi J. KerteszElectrophysiology

Discussion

Member takes

Implication

Clinical study identifies key predictors of recurrent supraventricular tachycardia in infants, highlighting factors that guide antiarrhythmic management.

Key Points

To identify clinical characteristics and prognostic factors associated with the recurrence of supraventricular tachycardia during infancy.
Evaluated clinical presentation, baseline electrocardiograms, and antiarrhythmic regimens in infants diagnosed with supraventricular tachycardia.
Analyzed clinical variables to determine predictors correlated with recurrent tachyarrhythmia episodes during follow-up.
Distinct clinical and electrophysiological characteristics correlate with an increased risk of supraventricular tachycardia recurrence in infancy.
Early risk stratification enables clinicians to tailor antiarrhythmic therapy and monitor high-risk infants more effectively.

Study Design

Type

Cohort (n=460)

Multicenter

PICO

Population

460 infants with structurally normal hearts diagnosed with re-entrant SVT at age ≤1 year, followed for a median of 5.2 years.

Exposure / Comparator

Wolff-Parkinson-White (WPW) syndrome vs Absence of WPW syndrome

Primary Outcome

First SVT recurrence after hospital discharge — HR 2.46 (1.75-3.45)

Main Result

Hazard Ratio: 2.46 (95% CI 1.75–3.45)

Cite This Study

Moore et al. (2022) conducted a cohort in Supraventricular tachycardia (SVT) (n=460). Wolff-Parkinson-White (WPW) syndrome vs. Absence of WPW syndrome was evaluated on First SVT recurrence after hospital discharge (HR 2.46, 95% CI 1.75-3.45). Wolff-Parkinson-White syndrome was the strongest predictor of SVT recurrence in infants (HR 2.46; 95% CI 1.75-3.45), alongside fetal or late diagnosis and need for multi-antiarrhythmic therapy.

synapsesocial.com/papers/6a99e43f3f99f84a4c1ebe6d https://doi.org/10.1016/j.jacc.2022.06.038

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Implication

Clinical study identifies key predictors of recurrent supraventricular tachycardia in infants, highlighting factors that guide antiarrhythmic management.

Clinical Predictors of Recurrent Supraventricular Tachycardia in Infancy

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Clinical Predictors of Recurrent Supraventricular Tachycardia in Infancy

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

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