A Brief Review of Antifungal Drugs Old and New

Advances in chemotherapy, immunotherapy, and the treatment of HIV have had a tremendous positive impact on survival and have decreased disease-related morbidity. However, such therapies have increased the number of patients with a compromised immune system thereby predisposing to opportunistic fungal infections. Despite currently available antifungal drugs, mortality rates remain elevated. Drug approvals for cancer, HIV, and transplantation continue and have significantly outpaced antifungal drug therapy development. Here, a brief review of current therapies is presented as well as investigational antifungal agents with novel mechanisms of action or molecular targets.