Anti-inflammatory Potential of a Novel Imidazole Containing Murrayanine Based Chalcone

Murrayanine is an active carbazole compound present in the Indian Curry tree, known as Murraya koenigii L. belonging to the family Rutaceae. Traditionally, it is known to exhibit anti-anemic, febrifuge, carminative, stomachic, purgative, astringent, and anti-helminthic. The present research involved the synthesis of (E)-3-(4-(1H-imidazol-1-yl)phenyl)-1-(1-methoxy-9H-carbazol-3-yl)prop-2-en-1-one from murrayanine and 4-(imidazol-1- yl)acetophenone and exploring the anti-inflammatory activity of the fabricated hybrid. The current effort involved screening the significance of imidazole function present in the ring-B of the murrayanine-chalcone scaffold and their further optimization thereof with emphasis on structural aspects. A moderate edema reducing potential has been seen in the newly developed compound (3). As compared with the indomethacin, the standard drug, the chalcone exhibited impressive anti-inflammation effect after 3hrs.