Key result
mTOR-mediated phosphorylation of Ser245 regulates NBCe1 functional expression, contributing to the response of astrocytes to acid/base challenges during pathophysiological conditions.
mTOR-mediated phosphorylation of NBCe1 regulates its functional expression in astrocytes, potentially contributing to their response to acid/base challenges.
Hypothesis-generating for astrocytic acid-base regulation; leaves open validation and clinical relevance in humans.
as a novel regulator of NBCe1 functional expression. We propose that context-dependent and mTOR-mediated multisite phosphorylation of serine residues of NBCe1 is likely to be a potent mechanism contributing to the response of astrocytes to acid/base challenges during pathophysiological conditions.
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A 2022 study studied this question. mTOR-mediated phosphorylation of Ser245 regulates NBCe1 functional expression, contributing to the response of astrocytes to acid/base challenges during pathophysiological conditions.
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