What question did this study set out to answer?

To establish an animal model of pulmonary hypertension secondary to respiratory syncytial virus (RSV) bronchiolitis that mimics the disease etiology observed in human infants.

June 15, 2018AJP Heart and Circulatory PhysiologyOpen Access

New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis

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To establish an animal model of pulmonary hypertension secondary to respiratory syncytial virus (RSV) bronchiolitis that mimics the disease etiology observed in human infants.
Infected neonatal mice with RSV at 5 days of life and reinfected them 4 weeks later, utilizing age-matched mice receiving serum-free medium as controls.
Assessed hemodynamics via right jugular vein catheterization for right ventricular systolic pressure (RVSP), pulsed-wave Doppler echocardiography, pulse oximetry, and lung morphometry.
RSV-infected mice demonstrated significantly higher RVSP alongside significantly shortened pulmonary artery acceleration time and decreased acceleration-to-ejection time ratios compared to controls, without evidence of hypoxia.
Morphometric analysis revealed significantly increased pulmonary artery medial wall thickness and an increased number of muscularized pulmonary arteries in RSV-infected mice relative to controls.

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Implication

Preclinical study demonstrates pulmonary hypertension following respiratory syncytial virus infection in neonatal mice, highlighting a novel platform for therapeutic testing.

Cite This Study

Kimura et al. (2018) studied this question.

synapsesocial.com/papers/6a99e73b4e49e699219e3e55 https://doi.org/10.1152/ajpheart.00627.2017

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Implication

Preclinical study demonstrates pulmonary hypertension following respiratory syncytial virus infection in neonatal mice, highlighting a novel platform for therapeutic testing.

New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis

Key Points

Discussion

Implication

Cite This Study

New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis

Key Points

Discussion

Implication

Cite This Study

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