Key result
Valsartan or aliskiren suppressed saturated fatty acid-induced endoplasmic reticulum stress in cultured human proximal tubule cells and in mice fed a high-fat diet.
Intrarenal RAS activation mediates saturated fatty acid-induced ER stress, suggesting a mechanism for diabetic kidney injury and a potential therapeutic role for RAS blockade.
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Hypothesis-generating for RAS blockade mitigating lipotoxic kidney injury; human trials needed before any practice change.
Li et al. (2015) studied Obesity-related kidney disease. Valsartan or aliskiren vs. Control was evaluated on Endoplasmic reticulum stress markers (BiP, CHOP, IRE1α, p-eIF2α, ATF4). Valsartan or aliskiren suppressed saturated fatty acid-induced endoplasmic reticulum stress in cultured human proximal tubule cells and in mice fed a high-fat diet.
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