What question did this study set out to answer?

To review recent advances in chiral phosphoric acid catalysis for the enantioselective synthesis of biologically active, enantioenriched indole derivatives.

June 24, 2015Synthesis

Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives

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Authors

HWHua WuNational Center for Drug Screening FSFeng ShiCornell University YHYu‐Ping HeShanghai University

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Implication

Literature review demonstrates diverse chiral phosphoric acid pathways for synthesizing enantiopure indoles, highlighting accessible routes to bioactive compounds.

Key Points

To review recent advances in chiral phosphoric acid catalysis for the enantioselective synthesis of biologically active, enantioenriched indole derivatives.
Classified synthetic strategies by reaction modality, including asymmetric additions, cycloadditions, cascade transformations, rearrangements, and kinetic resolution.
Surveyed dual-catalytic platforms incorporating chiral phosphoric acids with transition metals or auxiliary organocatalysts.
Chiral phosphoric acids enable the direct construction of structurally diverse, enantiomerically pure indoles from accessible starting substrates under mild reaction conditions.
Asymmetric 1,2- and 1,4-additions along with [3+2], [4+2], and [3+3] cycloadditions provide robust access to stereocenters across distinct indole positions.
Multi-catalytic cascade processes combining organocatalysts with transition metals significantly broaden reaction complexity and stereochemical control.

Cite This Study

Wu et al. (2015) studied this question.

synapsesocial.com/papers/6a99e7dde87681eadfde8d28 https://doi.org/10.1055/s-0034-1378837

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Implication

Literature review demonstrates diverse chiral phosphoric acid pathways for synthesizing enantiopure indoles, highlighting accessible routes to bioactive compounds.

Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

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