Inhibition of NF-Kappa B Activation by Penicillic Acid and Dihydropenicillic Acid Isolated from Fungi

In the course of our screening of NF-κB inhibitors from microbial secondary metabolites, we isolated two 2(5H)-furanones, penicillic acid and dihydropenicillic acid, from the culture filtrate of Penicillium.Both penicillic acids inhibited LPS-induced NO production and NF-κB activation.They did not inhibit protein synthesis.Interestingly, penicillic acid inhibited advanced glycation end product (AGE)-induced NO production.